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Ivermectin(IVM)
SINOBIO
29322090
Name: Ivermectin(IVM)
CAS: 70288-86-7
Chemical formula: C48H74O14
Appearance: White or yellowish-Crystalline powder
Ivermectin(IVM) is a new type of highly efficient semi synthetic antibiotic that kills insects, mites, and nematodes. It belongs to the category of insect neurotoxins and biological penetrating agents. Ivermectin is a new type of broad-spectrum, efficient, and low toxicity antibiotic type antiparasitic drug, which has good repellent effects on both internal and external parasites, especially nematodes and arthropods. But it is ineffective for tapeworms, flukes, and protozoa. The repellent effect of macrolide antiparasitic drugs on nematodes and arthropods is to increase the inhibitory neurotransmitter of Chemicalbook parasites γ- The release of aminobutyric acid (GABA) and the opening of glutamate controlled Cl ion channels enhance the permeability of the nerve membrane to Cl, thereby blocking the transmission of nerve signals, ultimately leading to nerve paralysis and loss of muscle cell contraction ability, leading to parasite death.
| Product Name | Ivermectin | |
| Cas No.: | 70288-86-7 | |
| EINECS No | 274-536-0 | |
| Reference | USP | |
| Test Item | Specification.EP | Test results |
| Appearance | White or yellowish-white crystalline powder | White-crystalline powder |
| Appearance of solution | The solution is clear and not more intensely Coloured than reference solution BY7 | Clear |
| Identification IR HPLC | Corresponds with that of CRS standard The retention time for H2B1a and H2B1b Corresponds to CRS | Complies |
| Water | Not more than 1.0% | 0.15 |
| Ethanol | Not more than 5.0% | 3.3 |
| Formamide | Not more than 3.0% | 2.0 |
| Ratio H2B1a /(H2B1a+ H2B1b),a | Not less than 90.0% | 95.2 |
| Assay(H2B1a+ H2B1b) (anhydrous and solvent-free substance) | 95.0%~102..0% Between95.0% and 102.0% | 97.5 |
| Related compounds | 1:Theindividual impurity(RRT1.3-1.5),Not more than 2.5% 2:Any other individual impurity not more than 1% 3:Sum of total impurities not more than 5% 4:Disregard peaks less than 0.05% | 1:1.50 2:0.50 3:2.1 4:0.05 |
| Heavy metals | Not more than 20ppm | <20ppm |
| Sulphated ash | Not more than 0.1% | <0.07 |
| Specific optical rotation(anhydrous and solvent-free substance) | Between-17o--20o | -19o |
| Residual solvents | Not more than 890ppm | <890ppm |
| Conclusion | Complies with the requirement of USP | |
In veterinary medicine ivermectin powder is used against many intestinal worms (but not tapeworms), most mites, and some lice. Despite this, it is not effective for eliminating ticks, flies, flukes, or fleas. It is effective against larval heartworms, but not against adult heartworms, though it may shorten their lives. The dose of the medicine must be very accurately measured as it is very toxic in over-dosage.
It is sometimes administered in combination with other medications to treat a broad spectrum of animal parasites. Some dog breeds (especially the Rough Collie, the Smooth Collie, the Shetland Sheepdog, and the Australian Shepherd), though, have a high incidence of a certain mutation within the MDR1 gene (coding for P-glycoprotein); affected animals are particularly sensitive to the toxic effects of ivermectin.
Clinical evidence suggests kittens are susceptible to ivermectin toxicity. A 0.01% ivermectin topical preparation for treating ear mites in cats (Acarexx) is available.
Ivermectin is sometimes used as an acaricide in reptiles, both by injection and as a diluted spray. While this works well in some cases, care must be taken, as several species of reptiles are very sensitive to ivermectin. Use in turtles is particularly contraindicated.
1. It is the derivatives of abamectin. Ivermectin belongs to oral semisynthetic broad-spectrum drug resistant parasites.
2. It has effect for most of the various life cycle nematodes.
3. It has effect for the microfilaria of onchocerca volvulus,but it does not has effect for the adult onchocerca volvulus.
4. It has effect for dung round worms that is only stay in intestinal tract.
5. It has selective inhibition.
6. It can not go through the blood brain barrier of humanbeings.
Packing: 1kg / aluminum foil bag, 25kg /drum. We provide customized package for different quantity.
Shipping: by express DHL,FEDEX,TNT......or as your requirement.
Payment: T/T,western union,moneygram or as your requirement.
Name: Ivermectin(IVM)
CAS: 70288-86-7
Chemical formula: C48H74O14
Appearance: White or yellowish-Crystalline powder
Ivermectin(IVM) is a new type of highly efficient semi synthetic antibiotic that kills insects, mites, and nematodes. It belongs to the category of insect neurotoxins and biological penetrating agents. Ivermectin is a new type of broad-spectrum, efficient, and low toxicity antibiotic type antiparasitic drug, which has good repellent effects on both internal and external parasites, especially nematodes and arthropods. But it is ineffective for tapeworms, flukes, and protozoa. The repellent effect of macrolide antiparasitic drugs on nematodes and arthropods is to increase the inhibitory neurotransmitter of Chemicalbook parasites γ- The release of aminobutyric acid (GABA) and the opening of glutamate controlled Cl ion channels enhance the permeability of the nerve membrane to Cl, thereby blocking the transmission of nerve signals, ultimately leading to nerve paralysis and loss of muscle cell contraction ability, leading to parasite death.
| Product Name | Ivermectin | |
| Cas No.: | 70288-86-7 | |
| EINECS No | 274-536-0 | |
| Reference | USP | |
| Test Item | Specification.EP | Test results |
| Appearance | White or yellowish-white crystalline powder | White-crystalline powder |
| Appearance of solution | The solution is clear and not more intensely Coloured than reference solution BY7 | Clear |
| Identification IR HPLC | Corresponds with that of CRS standard The retention time for H2B1a and H2B1b Corresponds to CRS | Complies |
| Water | Not more than 1.0% | 0.15 |
| Ethanol | Not more than 5.0% | 3.3 |
| Formamide | Not more than 3.0% | 2.0 |
| Ratio H2B1a /(H2B1a+ H2B1b),a | Not less than 90.0% | 95.2 |
| Assay(H2B1a+ H2B1b) (anhydrous and solvent-free substance) | 95.0%~102..0% Between95.0% and 102.0% | 97.5 |
| Related compounds | 1:Theindividual impurity(RRT1.3-1.5),Not more than 2.5% 2:Any other individual impurity not more than 1% 3:Sum of total impurities not more than 5% 4:Disregard peaks less than 0.05% | 1:1.50 2:0.50 3:2.1 4:0.05 |
| Heavy metals | Not more than 20ppm | <20ppm |
| Sulphated ash | Not more than 0.1% | <0.07 |
| Specific optical rotation(anhydrous and solvent-free substance) | Between-17o--20o | -19o |
| Residual solvents | Not more than 890ppm | <890ppm |
| Conclusion | Complies with the requirement of USP | |
In veterinary medicine ivermectin powder is used against many intestinal worms (but not tapeworms), most mites, and some lice. Despite this, it is not effective for eliminating ticks, flies, flukes, or fleas. It is effective against larval heartworms, but not against adult heartworms, though it may shorten their lives. The dose of the medicine must be very accurately measured as it is very toxic in over-dosage.
It is sometimes administered in combination with other medications to treat a broad spectrum of animal parasites. Some dog breeds (especially the Rough Collie, the Smooth Collie, the Shetland Sheepdog, and the Australian Shepherd), though, have a high incidence of a certain mutation within the MDR1 gene (coding for P-glycoprotein); affected animals are particularly sensitive to the toxic effects of ivermectin.
Clinical evidence suggests kittens are susceptible to ivermectin toxicity. A 0.01% ivermectin topical preparation for treating ear mites in cats (Acarexx) is available.
Ivermectin is sometimes used as an acaricide in reptiles, both by injection and as a diluted spray. While this works well in some cases, care must be taken, as several species of reptiles are very sensitive to ivermectin. Use in turtles is particularly contraindicated.
1. It is the derivatives of abamectin. Ivermectin belongs to oral semisynthetic broad-spectrum drug resistant parasites.
2. It has effect for most of the various life cycle nematodes.
3. It has effect for the microfilaria of onchocerca volvulus,but it does not has effect for the adult onchocerca volvulus.
4. It has effect for dung round worms that is only stay in intestinal tract.
5. It has selective inhibition.
6. It can not go through the blood brain barrier of humanbeings.
Packing: 1kg / aluminum foil bag, 25kg /drum. We provide customized package for different quantity.
Shipping: by express DHL,FEDEX,TNT......or as your requirement.
Payment: T/T,western union,moneygram or as your requirement.
